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Diabetes: An upcoming public health burden

Thu Jul 15

Diabetes or Diabetes Mellitus is a metabolic disorder in our body characterized by hyperglycemia or in simple words an increased concentration of glucose in our blood due to lack of insulin in our body. The condition can be considered to be an incident due to the poor lifestyle of the people and no proper nutritional diets. More than 400 million people in the world are going through this condition and it is estimated that more than 100 million will be added to the number in the coming 10 years. Diabetes can be Type 1 and Type 2 diabetes depending on the reason that causes the lack of insulin. Both these conditions are discussed briefly below. (Diabetes really a Public Health Burden?)

Type I and Type II diabetes mellitus

The main cause for hyperglycemia or increased concentration of glucose in the blood is the lack of insulin. What causes the lack of insulin differentiates diabetes into various types. Out of various types Type, I and Type II are major concerns. In Type I diabetes, the lack of insulin is caused due to auto-immune destruction of the beta cells in the islets of the pancreas which creates insulin in our body. Under Type II diabetes Mellitus, the body is unable to use the insulin or respond to it also known as insulin resistance. This Type II diabetes is incident in over 90% of the people hence a major concern.

Treatment for Type II Diabetes

Type II diabetes is more common and based on the cause for this disorder we can say it can be treatable by lifestyle and diet changes. Along with these 2 changes measures, medication is also required to treat the condition. Among the various medications available in the market two of the most common ones are Pioglitazone and Metformin but which one of them is more effective is discussed here where we will provide you basic details you need to know before taking any of the medicine. (Diabetes really a Public Health Burden?)


Pioglitazone is an oral anti-diabetic medicine that reduces the glucose level of our body by working at the molecular level where it modulates the transcription of genes involved in glucose control in muscle, liver, and adipose tissue. In this way, it leads to a reduction in insulin resistance in our bodies. Various common side effects caused by this medicine are listed below

  • Swelling
  • Headache
  • Muscle pain
  • Inflammation. 

Apart from this, some serious side effects are osteoporosis, heart failure, or bladder cancer although these serious side effects are rare. Pioglitazone is known to interact with other medications which are taken to lower blood glucose level which results in a reduction in the efficacy of the medicine. Also, Pioglitazone also reduces the effectiveness of oral contraceptives. (Diabetes really a Public Health Burden?)

Market size estimation 

Based on the report’s sales of Pioglitazone exceeds 2.4 billion USD making it one of the most selling medicines in the USA.

Metformin | Public Health Burden

Metformin, sold under the brand name Glucophage and others, is also an oral anti-diabetic medication, particularly for overweight people. The exact mechanism of action of metformin is not yet understood but based on different studies it is concluded that metformin reduces the activation of protein kinase or inhibits certain mitochondrial activities in the cells which ultimately leads to a reduction in insulin resistance in our body. The medicine is taken orally under fasting conditions. Various side effects which can be caused by the medicine are listed below:

  • Nausea
  • Diarrhea 
  • Abdominal pain
  • Gastrointestinal disorders

The above mentioned are common side effects that are generally less incident and also well-tolerated in the patients. Apart from the side effects, Metformin has a risk of causing low blood sugar in the body. 

Market size estimation of Metformin

Based on various reports metformin has more than 83 million prescriptions and is the fourth most commonly prescribed medicine in the USA. Based on this we can say that the market size of Metformin is more than Pioglitazone. (Public Health Burden)

Pioglitazone vs Metformin: Which is better

Based on various reports it can be concluded and also on the working of medicine Pioglitazone can be considered as a replacement for Metformin however considering the serious side effects of Pioglitazone cannot be prescribed to every person with diabetes for whom metformin is the number one option. Thus which medicine is better can be determined by the condition of the patient. 

Where can I Buy Pioglitazone and Metformin online?

Anti Diabetic medications are commonly prescribed medications which are available at every single store nearby and you can also order Pioglitazone online or purchase Metformin online from various online sellers. Although various websites are present in the online market from where you can get both Pioglitazone and Metformin at minimum prices, however, we recommend you to look first for authentic sellers which do not sell fake medication. You can consider purchasing Metformin from our store where we sell cheap and Genuine tablets. From our store, you can also order Metform online on COD where you do not need to make any advance payment or share your card details.

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